Dr. Markus Hecker

Publications

Dr. Hecker has published over 250 scientific peer-reviewed articles, 7 peer-reviewed book chapters, and 1 edited book. Featured are select publications from his repertoire.

  1. da Silva Junior F.C., Lin J., Hecker M., Batistuzzo de Medeiros S.R. 2025. Unveiling the Molecular Responses of Human Lung Cells to Retene: Transcriptomics Insights and Implications for Toxicity. Environ Toxicol Pharmacol 119:104828. https://doi.org/10.1016/j.etap.2025.104828
  2. Damdam, S., Hunnie, B., Jones, P., Hecker, M., Brinkmann, M., da Silva Junior, F.C. (2025) Toxicity assessment of 6PPD-quinone in human lung cells: Insights from BEAS-2B and A549 cell lines. Toxicology in Vitro 110: 106147
  3. Rachamalla M., da Silva Junior F.C., Hecker M., Niyogi S. 2025. Transgenerational inheritance of cognitive deficits induced by ancestral arsenic exposure in zebrafish (Danio rerio) via maternal and paternal lineages. Environ. Sci. Technol. 59(20):9930–9942.
  4. Ankley, P.J., da Silva, F.C., Hunnie, B., Roberts, C., Eriksson, A.N.M., Kohlman, E., Corker, J., Westcott, J., Germain, B., Martin, M.J., Dubiel, J., Anderson-Bain, K., Urrutia, R.M., Hogan, N., Giesy, J.P., Wiseman, S., Krol, E., Hecker, M., Brinkmann, M. (2024) Xenometabolome of Early-Life Stage Salmonids Exposed to 6PPD-Quinone. bioRxiv: 2024.06. 12.598661.
  5. Selinger, S., Montgomery, D., Wiseman, S., Hecker, M., Weber, L., Brinkmann, M., Janz, D. (2025) Acute cardiorespiratory effects of 6PPD-quinone on juvenile rainbow trout (Oncorhynchus mykiss) and Arctic char (Salvelinus alpinus). Aquatic Toxicology: 107288.
  6. Alcaraz A.J., Murray S., Ankley P., Park B., Raes K., Kurukulasuriya S., Crump D., Basu N., Brinkmann M., Hecker M.*, Hogan N. 2025. Transcriptomics points-of-departure (tPODs) to support hazard assessment of benzo[a]pyrene in early-life-stage rainbow trout. Environ. Sci. Technol. 59(14):6971-6982.
  7. Roberts, C., Lin, J., Kohlman, E., Jain, N., Amekor, M., Alcaraz, A.J., Hogan, N., Hecker, M.*, Brinkmann, M. (2025) Acute and Subchronic Toxicity of 6PPD-Quinone to Early Life Stage Lake Trout (Salvelinus namaycush). Environmental Science & Technology: 59:791-797.
  8. Selinger, S., Hunnie, B., Roberts, C., Amekor, M., Hogan, N., Wiseman, S., Hecker, M., Weber, L., Janz, D., Brinkmann, M. (2025) Sublethal 6PPD-quinone exposure impairs swimming performance and aerobic metabolism in juvenile lake trout (Salvelinus namaycush). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 294: 110166.
  9. Ankley, P.J., da Silva, F.C., Montgomery, D., Schultz, M., Krol, E., Hecker, M., Brinkmann, M. (2024) Biotransformation of 6PPD-quinone In Vitro Using RTL-W1 Cell Line. Environmental Science & Technology Letters 11(7): 687-693.
  10. Roberts, C., Kohlman, E., Jain, N., Amekor, M., Alcaraz, A.J., Hogan, N., Brinkmann, M., Hecker, M. (2024) Subchronic and Acute Toxicity of 6PPD-Quinone to Early Life Stage Rainbow Trout (Oncorhynchus mykiss). Environmental Science & Technology 59: 6771-6777.
  11. Esser M, Brinkmann M, Hecker M. 2024. Solving freshwater conservation challenges through next-generation sequencing approaches. Environ. Sci.:Adv. https://doi.org/10.1039/D4VA00112E
  12. Chen J., Wang C., Tu W., Zhang K., Fent K., Dai J., Hecker M., Giesy J.P., Zhoa J. 2024. AOP-Anchored Transcriptome Analysis Catalogue Accelerates the Discovery of Environmental Toxicants in Zebrafish. Environ. Sci. Technol. 58(30):13226-13238.
  13. Gasque-Belz L, Raes K, Park B, Colville C, Siciliano SD, Hogan N, Weber L, Campbell P, Peters R, Hanson M, Hecker M. 2024. Hazard assessment of complex legacy-contaminated groundwater mixtures using a novel approach method in adult fathead minnows. J Hazard Mat 465:133299. https://doi.org/10.1016/j.jhazmat.2023.133299
  14. Mitchell C.A., Burden N., Bonnell M., Hecker M., Hutchinson T.H., Jagla M., LaLone C.A., Lagadic L., Lynn S.G.., Shore B, Song Y., Vliet S., Wheeler J.R., Embry M.R. 2023. New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians. Environ. Toxicol. Chem. 42:757-777.
  15. Montgomery, D., Ji, X., Cantin, J., Philibert, D., Foster, G., Selinger, S., Jain, N., Miller, J., McIntyre, J., de Jourdan, B., Wiseman, S., Hecker, M.*, Brinkmann, M. (2023) Interspecies Differences in 6PPD-Quinone Toxicity Across Seven Fish Species: Metabolite Identification and Semiquantification. Environmental Science & Technology 57(50): 21071-21079.
  16. Mahoney, H., da Silva Junior, F.C., Roberts, C., Schultz, M., Ji, X., Alcaraz, A.J., Montgomery, D., Selinger, S., Challis, J.K., Giesy, J.P., Weber, L., Janz, D., Wiseman, S., Hecker, M., Brinkmann, M. (2022) Exposure to the Tire Rubber-Derived Contaminant 6PPD-Quinone Causes Mitochondrial Dysfunction In Vitro. Environmental Science & Technology Letters 9: 765-771.
  17. Anderson-Bain K., Roberts C., Kohlman E., Ji X., Alcaraz A.J., Miller J., Gangur-Powell T., Weber L., Janz D., Hecker M., Montina T., Brinkmann M., Wiseman S. 2023. Apical and mechanistic effects of 6PPD-quinone on different life-stages of the fathead minnow (Pimephales promelas). Comp Biochem Physiol C 271:109697.
  18. Hecker M., Peijnenburg W., Lam P.K., Brinkmann M. 2023. Emerging issues in aquatic toxicology – Plastic pollution. Aquat. Toxicol. 264:106729.
  19. Brinkmann, M., Montgomery, D., Selinger, S., Miller, J.G.P., Stock, E., Alcaraz, A.J., Challis, J.K., Weber, L., Janz, D., Hecker, M.*, Wiseman, S. (2022) Acute toxicity of the tire rubber-derived chemical 6PPD-quinone to four fishes of commercial, cultural, and ecological importance. Environmental Science and Technology Letters 9: 333-338.
  20. Crump D., Hickey G., Boulanger E., Masse A., Head J.A., Hogan N., Maguire S., Xia J., Hecker M., Basu N. 2023. Development and initial testing of EcoToxChip, a novel toxicogenomics tool for environmental management and chemical risk assessment. Environ Toxicol Chem. https://doi.org/10.1002/etc.5676
  21. Gasque-Belz L., Colville C., Kurukulasuriya S., Siciliano S.D., Hogan N., Weber L., Campbell P., Peters R., Hanson M., Hecker M. 2023. Characterization of molecular and apical effects of legacy-contaminated groundwater on early life stages of fathead minnows. Aquat. Toxicol. 264:106734.
  22. Alcaraz A.J., Mikulášek K., Potěšil D., Park B., Shekh K., Ewald J., Burbridge C., Zdráhal Z., Schneider D., Xia J.,  Crump D., Basu N., Hogan N., Hecker M*. 2021. Assessing the Toxicity of 17α-Ethinylestradiol in Rainbow Trout Using a 4-Day Transcriptomics Benchmark Dose (BMD) Embryo Assay. Environ. Sci. Technol. 55(15):10608-10618.
  23. Mangold-Doering A., Grimard C., Green D., Peterson S., Nichols J.W., Hogan N., Weber L., Hollert H., Hecker M., Brinkmann M. 2021. A Novel Multispecies Toxicokinetic Modeling Approach in Support of Chemical Risk Assessment. Environ. Sci. Technol. 55:9109-9118.
  24. Mondou M., Maguire S., Pain G., Crump D., Hecker M., Basu N., Hickey G.M. 2021. Envisioning an international validation process for New Approach Methodologies in chemical hazard and risk assessment. Environ. Advances 4:100061.
  25. Pain G., Hickey G., Mondou M., Crump D., Hecker M., Basu N., Maguire S. 2020. Drivers and Obstacles to the Adoption of Toxicogenomics for Chemical Risk Assessment: Insights from Social Science Perspectives. Environ. Health Perspect. 128(10). DOI 10.1289/EHP6500.
  26. Shekh K., Alcaraz A.J., Niyogi S., Hecker M*. 2020. Comparative analyses of oxidative stress response and metallothionein induction in white sturgeon and rainbow trout during acute waterborne copper exposure. Comp. Biochem. Physiol. C 231:108723.
  27. Brinkmann M., Alharbi H.A., Fuchylo U., Wiseman S.B., Moriandi G.D., Peng H., Giesy J.P., Jones P.D., Hecker M*. 2020. Mechanisms of pH-dependent uptake of ionizable organic chemicals by fish from oil sands process-affected water (OSPW). Environ. Sci. Technol. 54: 9547-9555. https://doi.org/10.1021/acs.est.0c02522
  28. Basu N., Crump D., Head J., Hogan N., Maguire S., Xia J., Hickey G., Hecker, M*. 2019. EcoToxChip: A next-generation toxicogenomics tool for chemical prioritization and environmental management. Environ. Toxicol. Chem. 38(2): 279-288. DOI: 10.1002/etc.4309
  29. Hecker M., LaLone C. 2019. Adverse Outcome Pathways: Moving from a scientific concept to a globally accepted framework. Environ. Toxicol. Chem. 38(6):1152-1163.
  30. Doering J., Wiseman S., Giesy J. Hecker M. 2018. A cross-species quantitative adverse outcome pathway for activation of the aryl hydrocarbon receptor leading to early life stage mortality in birds and fishes. Environ. Sci. Technol. 52(13):7524-7533.
  31. LaLone C., Ankley G.T., Belanger S.E., Embry M.R., Hodges G., Knapen D., Munn S., Perkins E.J., Rudd M.A., Villeneuve D.L., Whelan M., Willett C., Zhang X., Hecker M*. 2017. Advancing the adverse outcome pathway framework—An international horizon scanning approach. Environ. Toxicol. Chem. 36:1411-1421.
  32. Villeneuve D.L., Crump D., Garcia-Reyero N., Hecker M., Hutchinson T., LaLone C.A., Landesmann B., Lettieri T., Munn S., Nepelska M., Ottinger M.A., Vergauwen L., Whelan M. 2014. Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. Tox. Sci. 142:312-320.
  33. Kramer V.J., Etterson M.A., Hecker M., Murphy C.A., Roesijadi G., Spade D.J., Spromberg J.A., Wang M., Ankley G.T. 2011. Adverse Outcome Pathways and Ecological Risk Assessment: Bridging to Population Level Effects. Environ. Toxicol. Chem. 30:64-76.
  34. Matthiessen P., Ankley G.T., Biever R.C., Bjerregaard P., Borgert C., Brugger K., Blankinship A., Chambers J., Coady K.K., Constantine L., Dang Z., Denslow N.D., Dreier D.A., Dungey S., Gray E., Gross M., Guiney P.D., Hecker M., Holbech H., Iguchi T., Kadlec S., Karouna‐Renier N.K., Katsiadaki I., Kawashima Y., Kloas W., Krueger H., Kumar A., Lagadic L., Leopold A., Levine S.L., Maack G., Marty S., Meador J., Mihaich E., Odum J., Ortego L., Parrott J., Pickford D., Roberts M., Schaefers C., Schwarz T., Solomon K., Verslycke T., Weltje L., Wheeler J.R., Williams M., Wolf J.C., Yamazaki K. 2017. Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine‐active substances. Integrated Environmental Assessment and Management 13:267-279.